Counterflow Centrifugation Systems
Korus™
Elutriation. Washing. One system.
Optimize your cells for downstream success with Korus™
The Korus system uses counterflow centrifugation to separate cells by size, density, and shape, preparing optimized starting material for cell therapy manufacturing. With flexible, configurable protocols for both cell enrichment and cell wash applications, Korus can be tailored to meet your specific process requirements and deliver consistent, high-quality material at every step.
The Korus™ system’s elutriation application:
- Gentle counterflow centrifugation preserves cell viability for improved downstream manufacturing performance.
- Results in improved downstream cell selection, recovery, and expansion.*
- Enriches the target cells you need while removing the cells and contaminants you don’t need
- Provides a stronger intermediary product for downstream processing.
*As compared to a commonly used wash platform.
Flexibility to configure your own protocol
Configure Korus™ standard elutriation and wash protocols to support process development, then standardize your settings for GMP manufacturing. You can define key operating parameters, including:
- Centrifuge speed
- Counterflow rate
- Counterflow ramp rate
- Elutriation volume
- Harvest volume
Higher cell purity, selection recovery, and growth
*In samples prepared with Korus™ elutriation protocol compared to samples prepared through CS5+ washing.
The Korus™ counterflow centrifugation system has been designed for ease-of-use:
- Easy to install, functionally closed, sterile single-use set
- Intuitive screen interface that guides operators through instrument setup
- One core technology to meet industry standards, from process development to commercial manufacturing
Up to 88.6% monocyte recovery and 75% monocyte purity. Isolation of monocytes for downstream processes such as dendritic cell (DC) maturation. Process: Loading, elutriation, harvest.
Enrich lymphocytes with up to 91% recovery and 90% purity delivering high-quality starting material for CAR-T and PBMC based workflows. Process: Loading, elutriation, concentration, harvest.
Maximizing cell recovery and contaminant removal. Standard media exchange streamlines the manufacturing workflow with volume reduction as a built-in feature. Process: Loading, wash optional media exchange, harvest.
The Korus™ counterflow centrifugation system operates on the principle of elutriation.
Elutriation is a process for separating cells based on their size, shape and density using a stream of fluid flowing in the opposite direction to the centrifugal force.
The benefits of elutriation are:
- Separation of target from non-target cells
- Gentle production of a non-pelleting cell bed
Korus™ system specifications
Wide processing volume range:
25 mL – 9 L
Single-use set loading time:
<5 minutes
Viability loss
<5%
Input volume range
25 mL – 9 L
Output volume range (user defined)
25 mL – 500 mL
Single-use set loading time
<5 minutes
Typical processing time
<1 hour typical
Lymphocyte elutriation
Monocyte elutriation with media exchange option
Cell wash with media exchange option
Display
Glove compatible color touchscreen
Control system
Supports 21 CFR Part 11 Compliance
Chamber volume
Two 50 mL chambers
Maximum operational RCF
1000 x g
Dimensions
W 1460 mm (57.5 in), H 760 mm (30 in), D 810 mm (32 in)1000 x g
195 kg (430 lb)
The Korus™ system by Invetech is for research, laboratory or cell therapy manufacturing processes use only. It is not intended as a medical device in therapeutic or diagnostic procedures. Customers are responsible for validating the use of Korus technology within their process or therapy. Consult all instructions, terms and warnings prior to use of the solutions and products. Failure to do so can result in damage or serious injury, including death. Ready-to-run turnkey systems may require minor configuration before sale and use depending on customer needs.
See if Korus fits your protocol.
Send us your starting material, target output, and downstream needs. We’ll show you which Korus configuration fits.
