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GMP Formulation and Fill Systems

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Automation systems for formulation and filling

Achieve large scale, end-to-end cell and gene therapy manufacturing.

Our versatile formulation and filling systems enable rapid configuration to meet your specific manufacturing needs. Accurately formulate and dispense liquid and fill output bags utilizing aseptic single-use disposables. 

Configurable to your needs

Take the assured pathway from process development to commercial manufacturing.

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Case study: Integrated media production system

Automated, closed cell and gene therapy manufacturing

Solving commercial manufacturing challenges in cell and gene therapy

Media

Viral vector

Cell product

Assured Pathways to commercial cell and gene therapy manufacturing

Our automation systems provide an articulated path to integrated commercial manufacturing, from pre-clinical phase to large-scale manufacturing, without any substantive process changes. All elements are robust, GMP compliant, closed, cleanable and validated.

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  • Aseptic closed disposables
  • Consistent product quality
  • Industrial platform in standard and configured versions

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This Invetech configurable platform helps achieve consistent product quality with tracked records and trusted manufacturing controls.

  • Bulk media formulation 50-250L batch size, multiple recipes
  • Coupled fill 0.25-5L for direct integration into drug product manufacturing
  • Complete batch delivered in a single shift by a single operator  
  • GMP, 21CFR11, eBR integrated
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A track record in cell and gene therapy commercial automation

Invetech has been working in custom commercial cell and gene therapy manufacturing since 2001. We’re committed to helping you successfully transition from clinical to commercial-scale manufacturing.

We’ve completed over 70 design and development projects for cell and gene therapy companies, helping them shorten their time to market and getting the treatment to patient.

viral vector formulation and bag filling station

Robust

  • Flexible recipes and batch sizes
  • Direct tech transfers across facilities
  • Standalone or fully integrated with eBR/MES

Scalable

Cost-effective

  • Operation in Class C/D cleanroom
  • Higher throughput for lower headcount
  • Complete system with equipment, disposables, service and support

Configurable platform enables base platforms to be configured for a broad range of formulation and filling applications, including processing final cell product or aliquoting cell suspensions for master and/or working cell banks.

Key platform capabilities
  • Automated bag seal and separate 
  • Temperature control for cell products and reagents 
  • PLC or DCS compatible 
  • Barcode scanner capable 
  • Class C/D cleanroom operation 
  • Single-use systems matched to equipment configuration

3rd Generation filling system

This system provides a fully automated platform for flexible bag filling by a single operator.

Media bag filling

Viral vector cryo-bag filling

Achieve large scale, end-to-end cell and gene therapy manufacturing

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  • Output bag size range 500 mL ~ 5 L 
  • Fill volume (per bag) 200 mL ~ 5 L 
  • Fill rate (100 mL fill) 20 bags in 1 hour
  • Output bag size range 50 mL ~ 500 mL 
  • Fill volume (per bag) 15 mL~ 200 mL 
  • Fill rate (100 mL fill) 72 bags in 2 hours

Configurations for cell product and cell banking

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