Automated Live Cell High-Content Screening Platform
We assisted in the creation of an in-house test platform for high-content screening of live cells to assist in drug screening process steps.Automating cell-based assays
CelTor Biosystems required an automated in-house test platform for high-content screening of live cells.
The system would be used in a range of drug discovery process steps from target validation to lead optimization. The complex workstation needed to combine high-performance fluorescent imaging with microfluidics technology for automation of cell-based assays.
While working with CelTor Biosystems in both Denmark and California, we developed:
- Fluidics workstation to deliver multichannel hydrodynamic flows
- Microfluidics chip to steer laminar multichannel hydrodynamic flows over a cell culture.
- Optics workstation that provides microscopic bright field and fluorescent imaging of cell culture in-situ on the microfluidics chip.
During development, we overcame a range of challenges, including complex multi-lane microfluidics, high-performance fluorescence cellular imaging, systems integration to enable previously unfeasible cellular assays, and a fast development timeframe.
We developed a proprietary drug discovery platform within months, using base technology and integrating commercial autosamplers with complex fluidics and high-performance fluorescence cellular imaging. The system enables previously unfeasible cellular assays for cell apoptosis and ADME/Tox.
Life Sciences & Biotech
Not all innovative or complex technology is used in the clinic, but these systems benefit from many of the same principles used.
Mid to High Throughput Instruments
Whether we support the entire product or take lead on a subsystem, full instrument architecture is critical to success.
Benchtop & Distributed
Translating technical workflows of an assay into an automated process performed within a device.
Custom Process Automation
Transition from clinical to commercial scale manufacturing with our production-ready manufacturing and automation solutions.