Automated live cell high-content screening platform

Client

CelTor Biosystems™

Product

Automating cell-based assays

CelTor Biosystems required an automated in-house test platform for high-content screening of live cells.

The system would be used in a range of drug discovery process steps from target validation to lead optimization. The complex workstation needed to combine high-performance fluorescent imaging with microfluidics technology for automation of cell-based assays.

While working with CelTor Biosystems in both Denmark and California, we developed:

Fluidics workstation to deliver multichannel hydrodynamic flows
Microfluidics chip to steer laminar multichannel hydrodynamic flows over a cell culture.

Optics workstation that provides microscopic bright field and fluorescent imaging of cell culture in-situ on the microfluidics chip.

During development, we overcame a range of challenges, including complex multi-lane microfluidics, high-performance fluorescence cellular imaging, systems integration to enable previously unfeasible cellular assays, and a fast development timeframe.

We developed a proprietary drug discovery platform within months, using base technology and integrating commercial autosamplers with complex fluidics and high-performance fluorescence cellular imaging. The system enables previously unfeasible cellular assays for cell apoptosis and ADME/Tox.

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