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KorusTM

Elutriation. Washing. One system.

Prepare cleaner cell populations
with the Korus™ system

Monocyte elutriation

Up to 78.6% monocyte purity and 70.1% recovery. Isolation of monocytes for downstream processes such as dendritic cell (DC) maturation.

Lymphocytes

Monocytes

1

INPUT

Lymphocytes and monocytes are loaded into the chamber from the input bag.

2

ELUTRIATION

Lymphocytes are eluted from the top of the chamber into the waste bag with the monocytes remaining at the bottom of the chamber.

3

HARVEST

Monocytes flow from bottom of chamber to harvest bag.

Lymphocyte elutriation

Up to 85.2% lymphocyte recovery and 90.3% purity, providing a cleaner starting material for CAR-T or TIL manufacturing.

Lymphocytes

Monocytes

1

INPUT

Lymphocytes and monocytes enter the chamber from the input bag. Excess input solution flows to waste.

2

ELUTRIATION

Lymphocytes leave the top of the chamber to the fraction bag with monocytes remaining at the bottom of the chamber.

3

CONCENTRATION

Lymphocytes are loaded into the chamber from the fraction bag. Excess buffer flows to waste.

4

HARVEST

Lymphocytes flow from bottom of chamber to harvest bag.

Cell wash

Maximizing cell recovery and contaminant removal.

Cells

1

INPUT

Cells are loaded into the chamber from the input bag. Excess input solution flows to waste.

2

WASH

Buffer flows through the chamber exchanging medium that the cells are suspended in and removing contaminants.

4

WASH

Cells flow from bottom of chamber to harvest bag.

Use of Korus™ in manufacturing processes

The steps in the process highlighted in green are where the Korus™ would be used.

CAR-T manufacturing process

DC manufacturing process

TIL manufacturing process

IPSC-derived therapy manufacturing process

What is elutriation?

The Korus™ counterflow centrifugation system operates on the principle of elutriation. Elutriation is a process for separating cells based on their size, shape and density using a stream of fluid flowing in the opposite direction to the centrifugal force.

The benefits of elutriation are:

  • Separation of target from non-target cells
  • Gentle production of a non-pelleting cell bed

Stages in the lymphocyte elutriation process:

1

Loading

Transfer of input cells into chamber(s).

3

Transfer fraction

Transfer of lymphocytes 
from fraction bag to chamber for concentration.

2

Elutriation

Increased counterflow removes smaller cells (lymphocytes) from chamber(s) to fraction bag.

4

Harvest

Transfer of cells from chamber to harvest bag in a user-defined volume.

Lymphocytes

Cells

Learn how to optimize your cells for downstream success with Korus™

The Korus system is for research, laboratory or further manufacturing use only. It is not intended as a medical device in therapeutic or diagnostic procedures. Customers are responsible for validating the use of Korus within their process or therapy. Consult all instructions, terms and warnings prior to use of the solutions and products. Failure to do so can result in damage or serious injury, including death. Ready-to-run turnkey systems may require minor configuration before sale and use depending on customer needs.

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