Reduce the risk of batch contamination
with our automated rapid fill system’s autoseal feature
Our award-winning automated rapid bag fill system can be used for:
- Autologous viral vector filling
- Allogeneic cell banking and final fill
- Media/reagent filling
Seal, separate, collect, repeat
The system has an automated sealing and separation feature that works with our fully-closed, sterile single-use set (SUS) to help reduce the risk of batch contamination. All SUS bags are automatically and individually weighed, reducing QA overhead. After each run, a final batch report is created that records any exceptions that occurred to help speed up your process efficiency.
This rapid fill system uses a sealing membrane to individually autoseal all 66 bags per manifold. Pictured is a view of the bags after they have been autosealed and separated just above the cryo storage bag to minimize the resulting length of fill tubing for easy storage.
Watch how you can power through up to hundreds of bags per shift
The rapid bag fill system can be configured to accurately and rapidly dispense therapeutic products or processing material from formulated bulk into individual aliquot bags
Using a closed-system SUS, you can achieve automated, closed, efficient and flexible bag filling in class C or D cleanroom settings. Designed for GMP manufacturing, this configurable system is scalable and minimizes process variability.
| Performance | |
| Output bag size range | 50 ml – 750 ml |
| Fill volume (per bag) | 15 ml – 200 ml |
| Total dispense volume | Up to 100 L depending on aliquot volume |
| Fill accuracy | 5% vol. or 1.5 g |
| Bags per manifold | Up to 66 |
| Batch capacity | 528 bags (via multiple manifolds) |
| Fill rate | Typically 1 bag per minute* |
*Actual fill times may vary based on fluid viscosity or other factors
From process development to commercial manufacturing
Robust
Closed, automated system for formulation and filling
Aseptic disposables matched to system configuration
Industrial build, control system options (PLC, DeltaV)
Connect with eBR, MES
Scalable
Create and utilize multiple protocols for batch sizes and fill volumes
Seamless tech transfer across global manufacturing sites
Cost-effective
Minimal footprint in lower grade cleanroom (C/D)
Single operator, intuitive interface
Auto seal/separate limits operator touch time
Precise transfers limit losses, improve manufacturing efficiency
Reduces lot-to-lot variability
Invetech GMP Formulation and Fill Systems
A track record in cell and gene therapy commercial automation
Invetech has been working in custom commercial cell and gene therapy manufacturing since 2001. We’re committed to helping you successfully transition from clinical to commercial-scale manufacturing.
We’ve completed over 70 design and development projects for cell and gene therapy companies, helping them shorten their time to market and getting the treatment to patient.
Contact us
Take the assured pathway from process development to commercial manufacturing.